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Biography:
Dr. Puglielli’s broad research interests focus on the role that lipid metabolism plays in the regulation of Aβ (amyloid β-peptide) generation and synaptogenesis during both normal aging of the brain and the Alzheimer-type of neurodegeneration. Specifically, we focus on the role played by the ceramide-dependent signaling cascade, and by intracellular cholesterol distribution.
Publications:
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Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults
April 12, 2016
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Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease
May 27, 2014
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Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer.
May 14, 2014
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Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study
May 1, 2013
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NSAIDs may protect against age-related brain atrophy
September 3, 2010
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Midlife predictors of Alzheimer's disease
December 29, 2009