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Auriel A Willette

Post doctoral fellow

Alzehimer's Disease Research Center
Clinical Science Center (J5/1M)-MC2420
600 Highland Ave
Madison, WI, 53792

Office: (608)262-6501 x
Lab:
Fax: (608)265-3091
Email: willette@wisc.edu
Web:

Biography:

The underlying neurobiological mechanisms mediating regional and global brain changes in neurodegenerative diseases, as well as normal aging, are poorly understood. I work with a non-human primate animal model (Macaca mulatta) to examine how immunological, cerebrovascular, and affective factors contribute to neural atrophy in old age using MRI. Long-term calorie restriction is used as an intervention to mitigate the impact of these physiological and behavioral indices.

Publications:

Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts
May 10, 2017
Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease
September 1, 2015
Insulin resistance predicts brain amyloid deposition in late middle-aged adults
May 1, 2015
Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: A fiber tractography study
May 21, 2014
Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques
December 1, 2013
Low cerebral blood flow is associated with lower memory function in metabolic syndrome.
July 1, 2013
Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study
May 1, 2013
White matter microstructural integrity and executive function in Parkinson’s disease
March 19, 2013
Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults
February 1, 2013
Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeys
November 8, 2012
CSF T-Tau/Ab42 Predicts White Matter Microstructure in Healthy Adults at Risk for Alzheimer’s Disease
June 6, 2012
Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys
May 6, 2012
Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeys
July 1, 2011
NSAIDs may protect against age-related brain atrophy
September 3, 2010
Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys
August 4, 2010
Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys
July 1, 2010
Effects of aging and calorie restriction on white matter in rhesus macaques.
June 11, 2010
A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys
June 9, 2010