Scientists
- Sterling Johnson
- Lindsay Clark
- Robert Cadman
- Gilda Ennis
- Ozioma Okonkwo
- Megan Zuelsdorff
- Barbara Bendlin
- Catherine Gallagher
- Vikas Singh
- Howard Rowley
- Tobey Betthauser
- Alex Birdsill
- Alice Motovylyak
Collaborators
Research Staff
- Nancy Davenport-Sis
- Kristina Kellett
- Kao Lee Yang
- Amy Hawley
- Rachel Spahnn
- Max Gaitan
- Bill Bevis
- Chuck Illingworth
- Caitlin Cleary
- Sarah Lose
- Lily Allison
- Kaitlin Maxa
- Colleen Mellert
- Clayton Vesperman
- Amy Barzgari
- Paul Cary
- Sara Frost
- Sandra Harding
- Garrett Haukoos
- Theresa Kang
- Mike Kelly
- Stephanie Krislov
- Grace McKinney
- Alexandria Moellner
- Jennifer Oh
- Mary-Elizabeth Pasquesi
- Leah Sanson
- Erica Smith
- Ingrid Taylor
Graduate Students
- Ryan Dougherty
- Claire Erickson
- Taylor Fields
- Margo Heston
- Jack Hunt
- Akshay Kohli
- Nick Vogt
- Katie Zarbock
Research Assistants
Auriel A Willette
Post doctoral fellow
Alzehimer's Disease Research Center
Clinical Science Center (J5/1M)-MC2420
600 Highland Ave
Madison, WI, 53792
Office:
(608)262-6501 x
Lab:
Fax:
(608)265-3091
Email:
willette@wisc.edu
Web:
Biography:
The underlying neurobiological mechanisms mediating regional and global brain changes in neurodegenerative diseases, as well as normal aging, are poorly understood. I work with a non-human primate animal model (Macaca mulatta) to examine how immunological, cerebrovascular, and affective factors contribute to neural atrophy in old age using MRI. Long-term calorie restriction is used as an intervention to mitigate the impact of these physiological and behavioral indices.
Publications:
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Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts
May 10, 2017
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Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease
September 1, 2015
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Insulin resistance predicts brain amyloid deposition in late middle-aged adults
May 1, 2015
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Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: A fiber tractography study
May 21, 2014
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Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques
December 1, 2013
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Low cerebral blood flow is associated with lower memory function in metabolic syndrome.
July 1, 2013
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Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study
May 1, 2013
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White matter microstructural integrity and executive function in Parkinson’s disease
March 19, 2013
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Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults
February 1, 2013
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Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeys
November 8, 2012
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CSF T-Tau/Ab42 Predicts White Matter Microstructure in Healthy Adults at Risk for Alzheimer’s Disease
June 6, 2012
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Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys
May 6, 2012
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Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeys
July 1, 2011
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NSAIDs may protect against age-related brain atrophy
September 3, 2010
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Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys
August 4, 2010
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Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys
July 1, 2010
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Effects of aging and calorie restriction on white matter in rhesus macaques.
June 11, 2010
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A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys
June 9, 2010