Neuropsychology Neuroimaging Lab

Special Topics in Neuroscience 675: 
Functional Imaging of Cognitive Disorders:

 

Neuroscience 675 and Psychology 711: Functional Imaging of Cognitive Disorders
 Public Website: http://www.brainmap.wisc.edu/neuro675F07.html
Protected Learn@UW Website: https://learnuw.wisc.edu/

Fall 2007, 3 credits

Instructor: Sterling C. Johnson, PhD
Email: scj@medicine.wisc.edu

TA: Donald McLaren
Email: dmclaren@wisc.edu

LOCATION: CSC  G5/113  

TIME: Tuesday 2:30 to 4:00 PM
            Thursday 2:30 to 4:00 PM
Exceptions:
November 6 is cancelled due to Society for Neuroscience.
November 22 is cancelled due to Thanksgiving.

— FORMAT:
2:30-3:30 Faculty lecture
3:30-4:00 Discussion of Paper or Lab on brain mapping techniques (will be announced prior to class)

— CONTEXT: Higher level brain functions such as appraisal, self-awareness, executive abilities, language memory form the basis of adaptive behavior and rich social interactions. In addition, these higher level functions may be modulated by lower level sensory processes (e.g. touch, audition, vision, emotion). In this course we will study these processes and some of the methods used to measure them in normal and previously normal brains.  
— APPROACH: The special issues involved in brain mapping cognitive disorders require a multidisciplinary approach. The first half of the semester will focus on methodological issues including experimental design and data analysis. For each area of focus, an expert in the area from UW has been invited to give the presentation. The presentation requires that students have read the selected readings. Following the presentation, there will be an extended discussion about the methods/papers or an example of the method. When papers are provided before class, students should read and understand its rationale, methods, results, interpretation, advantages and disadvantages.

— REQUIRED TEXT (available at the UW Bookstore):

—OPTIONAL TEXTS (Selected chapters available on LearnUW):

REQUIREMENTS:
— WEEKLY QUIZZES: Students are required to complete a quiz each week. Quizzes will have a 60 minute completion time and be available for Friday through Tuesday preceding the beginning of Tues class. Its on the learn@UW website.
— MIDTERM EXAM: After we have covered all of the methodological issues, there will be an exam. The exam will be available on the learnUW website for a period of one week. There will be no time limit for completion.
— ATTENDANCE/CLASS PARTICIPATION: Because the main component of the class is the seminar lecture series, your attendance at the seminar is essential. Further, to maximize the experience, we encourage you to be familiar with the readings for the day, and to interact with the speakers. To incentive this, 25% of your grade will be based on showing up and participating.  One point per session is given (for up to 25 of the 28 class sessions). You will not receive credit for missed classes. We will call upon individuals to answer questions about the papers.
— GRADUATE STUDENTS FINAL PAPER: Design a research protocol for an imaging study; assume that each participant can be scanned for between 90 and 120 minutes. Include a discussion group size, power analysis, pulse sequence choices, analysis of different anatomical images collected, fMRI experimental design, fMRI analysis, and expected results from the functional and anatomical images. Make sure you account for all the scanner time.
— UNDERGRADUATE STUDENTS FINAL PAPER: Design an fMRI experiment and the analysis procedures.
— GRADING:
15% for Quizzes
25% for Midterm
25% for ACTIVE Participation
35% for Final Paper

Schedule:

9/4/2007	Introduction to Functional Brain Mapping	Sterling Johnson, PhD
9/6/2007	Functional Neuroanatomy, Neurovasculature, and White Matter	Donald McLaren
9/11/2007	MRI I:  An introduction to MR Physics and MRI	Beth Meyerand, PhD
9/13/2007	MRI II:  Advanced MRI: BOLD, DTI, artifacts, field strength, limits	Andy Alexander, PhD
9/18/2007	White Matter Imaging and diseases, MS, DTI	Aaron Field, MD,PhD
9/20/2007	Diffusion Tensor Imaging and Diffusion Tensor Tractography	Andy Alexander, PhD
9/25/2007	Stroke Imaging using Perfusion/Diffusion	Howard Rowley, MD
9/27/2007	Image analysis and preprocessing	John Ollinger, PhD
10/2/2007	Data analysis with GLM	John Ollinger, PhD
10/4/2007	MRS and Functional Connectivity	Beth Meyerand, PhD
10/9/2007	Perfusion Imaging with spin labeling and susceptibility methods	Goufan Xu, MD, PhD
10/11/2007	Analyses of brain morphometry	Moo Chung, PhD
10/16/2007	Spatial Registration of brain images	Terry Oakes, PhD
10/18/2007	fMRI and anatomical analysis and the GLM	Donald McLaren
10/23/2007	Statistical Approaches to Image Analysis	Tim Hess, PhD
10/25/2007	Alzheimer's Disease I  Clinical Features	Carey Gleason, PhD
10/30/2007	Alzheimer's Disease II  Pre-symptomatic Brain Changes	Sterling Johnson, PhD
11/1/2007	Brain Mapping with PET, receptor and molecular imaging	Brad Christian, PhD
11/6/2007	NO CLASS. Society For Neuroscience.	----
11/8/2007	Alzheimer's Disease III (MCI, neural correlates of deficits)	Michele Ries, PhD
11/13/2007	Structural Changes in Normal Aging:	Barb Bendlin, PhD
11/15/2007	Parkinson's Disease	Catherine Gallagher, MD
11/20/2007
11/22/2007	NO CLASS. Thanksgiving Break.	----
11/27/2007	fMRI, TMS, Working Memory	Brad Postle, PhD
11/29/2007	Brain Plasticity I (Traumatic Brain Injury)	Barb Bendlin , PhD / Sterling Johnson, PhD
12/4/2007	Brain Plasticity II (Multi-modal Sensory Cortices)	Donald McLaren
12/6/2007	Pain	Dane Cook, PhD
12/11/2007	Anxiety and Depression	Jack Nitschke, PhD
12/13/2007	Autism	Dan Kelley