Rhesus macaque atlas templates for functional and structural imaging studies
March 11, 2008
One of the most critical developments in human neuroimaging research has been the creation of standard atlas templates for between participant registration and normalization. These atlases enable alignment of individual scans to improve localization and statistical power of the results, and allow comparison of results between studies and institutions. Presently, however, rhesus macaque (Macaca mulatta) imaging studies have been limited in their generalization by a lack of a common atlas composed from multiple individuals. Through a joint collaboration between the National Institute on Aging, Oregon Health and Science University and University of Wisconsin - Madison, we have constructed a new set of multi-sbuject atlas templates in order to facilitate functional and structural imaging studies of the rhesus macaque.
A large cohort of animals were assembled from the participating institutions and split into two broad age ranges based on their sex and age distribution. We are currently working to continue to expand the cohort to eventually produce an atlas representing a normally distributed population of animals across both sexes and the entire age range. Three atlases are presented here, an adult group, an elderly group and a combined group.
| Adults | Elderly | Polycohort | |
|---|---|---|---|
| Subjecs (N) | 47 | 24 | 71 |
| Minimum Age (months) | 85 | 294 | 85 |
| Maximum Age (months) | 258 | 387 | 387 |
| Mean Age (months) | 174.63 | 335.16 | 228.90 |
| Standard Deviation (months) | 29.99 | 26.74 | 81.69 |
Our poster from the Human Brain Mapping Annual Meeting 2007 contains additional information on our processing stream and a brief discussion:
Downloads:
| Adult | Elderly | Combined | |
|---|---|---|---|
| Atlas | |||
| Priors | |||
| HBM Poster | |||
